Early Postoperative Effect of Ripasudil Hydrochloride After Trabeculectomy on Secondary Glaucoma: A Randomized Controlled Trial

Purpose: To evaluate the effect of Rho-associated kinase inhibitor (ripasudil hydrochloride hydrate; ripasudil) eye drops on postoperative intraocular pressure (IOP) after trabeculectomy in eyes with uveitic glaucoma. Design: This was a prospective, observational, controlled, and randomized study. Methods: Sixteen 16 patients glaucoma who underwent without mitomycin C were randomly treated ripasudil (8 eyes) eyes). Postoperative IOP surgical outcomes 3 months surgery compared between two groups. Results: No patient discontinued treatment due to lack efficacy or adverse effects during 3-month study period group. The mean (mmHg) control groups 42.5 ± 9.8 mmHg /43.9 11.7 (p = 0.82) at baseline, 14.3 4.9 /9.0 3.7 0.04) 1 week, 16.3 4.2 /10.6 3.0 0.01) month, 16.0 3.4 /12.5 2.3 months. number laser suture lysis procedures (2.0 0.5 vs 0.4 0.7), rate bleb revision by needling (50.0% 0.0%), antiglaucoma medications (1.6 1.5 . 0.1 0.3) higher group than (all p < 0.05). A multivariate analysis showed that reduction associated use baseline Conclusion: demonstrated therapeutic efficacy, safety, tolerability for postoperatively. Ripasudil may effectively reduce increase success